Brie was born in Hollywood, California. Her mother is Jewish and her father is of Dutch, Irish, and Scottish origin. She started acting in 2004 at the Jewish Community Center in Southern California.

In “GLOW”, she hovers around 15-18 percent body fat. Brie has always been a petite woman, but she transformed her body for this role without changing her weight. The secret behind the actress's transformation was focusing on foundational strength while dropping body fat.

On The Drew Barrymore Show, Brie shared the rules for how her and Franco's marriage has lasted five years. “The first one is respect,” she shared. “I think we respect each other, and we are so kind to each other.

Alison Brie She and her husband, Dave Franco, decided not to have children because it would be too stressful. “I don't really want to have kids. It's great because I don't worry about when I should get pregnant — between seasons, while we're shooting the show — I don't think about it every day.”