Lexie Brooks (later Heck) is Axl Heck's wife and Sue Heck's college roommate at East Indiana State and best friend who, like Sue, fails to get accepted by any of the sororities at school. She later becomes Sue's dorm roommate. Sue later discovers that she's too poor to keep up with Lexie's spending habits.

Though it is not stated who he is married to in the finale, the seventh season episode "Halloween VI: Tick Tock Death" hints that Brick marries and starts a family with Cindy. Brick speaks the last line of dialogue in the series, repeating "the middle" in a whisper.

Greer Grammer as April, Axl's cute but very very dimwitted girlfriend whom he met over the summer. They briefly married before getting an annulment. They remain a couple until breaking up in the episode "Exes and Ohhhs". Casey Burke as Cindy Hornberger, Brick's quirky girlfriend.