In March 2008, she was hospitalized for lung complications, recovered, and reported to be doing well. Later that year, her husband, Wiley Burton, died after suffering from renal cancer. On December 13, 2018, Wilson died after a long illness at her home in Pioneertown, California. She was 81 years old.

Wilson has been lauded for her guitar playing, noted for its blending elements of flamenco and classical guitar styles with hard rock.

Nancy released her first solo album, You & Me, in 2021. Nancy recently revealed that she has also started writing with Ann again. “I've got a bunch of new ideas for songs,” said Wilson. “I've also been writing new music with Ann, too, so it's a real creative time.

Sixty years later, Ann and Nancy are still rocking, and they are leading the Rock and Roll Hall of Fame band Heart for its Royal Flush Tour across the U.S. Heart is being supported on the 2024 reunion tour by another Rock and Roll Hall of Fame group, Cheap Trick.