Nielsen's breakthrough in Hollywood came with her role as the intimidating, seductive Soviet agent Ludmilla Drago in the 1985 blockbuster film "Rocky IV." Her portrayal opposite Sylvester Stallone captivated audiences, showcasing her ability to command the screen and embody complex characters.

Nielsen has been married five times and has four sons and one daughter. Her first husband was Kasper Winding, to whom she was married from 1983 to 1984.

She continues to act in many films such as:She's Too Tall (1998), Body Count (1995), 976-Evil II (1991), Galaxis (1995) with Sam Raimi, Compelling Evidence (1995), Corey Feldman, George Hamilton, Snowboard Academy (1997), Hostile Environment (1999) and Doomsdayer (2000).

Strange Love followed Nielsen's often contentious relationship with Flavor Flav as well as her budding relationship with Dessi. The series ended with the Red Sonja star splitting from Flavor Flav and choosing to pursue a relationship with Dessi.